4.4 Article

A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

Journal

TETRAHEDRON
Volume 63, Issue 52, Pages 12954-12960

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.10.037

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A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields. (c) 2007 Elsevier Ltd. All rights reserved.

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