Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 26, Pages 6462-6464Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm7011497
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Funding
- NINDS NIH HHS [U01 NS058087-01, U01 NS058087, U01NS058087-01] Funding Source: Medline
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A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally. bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.
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