Journal
STATISTICS IN MEDICINE
Volume 26, Issue 30, Pages 5360-5369Publisher
WILEY
DOI: 10.1002/sim.3006
Keywords
cumulative incidence function; Fine and Gray model; baseline hazard; hospital infection
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After peripheral blood stem-cell transplantation, patients treated for severe haematologic diseases enter a critical phase (neutropenia). Analysis of bloodstream infection during neutropenia has to account for competing risks. Separate Cox analyses of all cause-specific hazards are the standard technique of choice, but are hard to interpret when the overall effects of covariates on the cumulative incidence function (CIF) are of interest. Proportional subdistribution hazards modelling of the subdistribution of the CIF is establishing itself as an interpretation-friendly alternative. We apply both methods and discuss their relative merits. Copyright 2007 John Wiley & Sons, Ltd.
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