Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 68, Issue 5, Pages 1393-1405Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2006.12.078
Keywords
norfloxacin; gold(III) complex; biological activity; kinetic data; infrared spectra
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The investigation of the new structures of Ag(I), Cu(II) and Au(III) complexes, [Ag-2(Nor)(2)](NO3)(2), [Cu(Nor)(2)(H2O)(2)]SO4 center dot 5H(2)O and [Au(Nor)(2) (H2O)(2)]Cl-3 (where, Nor=norfloxacin) was done during the reaction of silver(l), copper(II) and gold(III) ions with norfloxacin drug ligand. Elemental analysis of CHN, infrared, electronic, H-1 NMR and mass spectra, as well as thermo gravimetric analysis (TG and DTG) and conductivity measurements have been used to characterize the isolated complexes. The powder XRD studies confirm the amorphous nature of the complexes. The norfloxacin ligand is coordinated to Ag(I) and Au(III) ions as a neutral monodentate chelating through the N atom of piperidyl ring, but the copper(II) complex is coordinated through the carbonyl oxygen atom (quinolone group) and the oxygen atom of the carboxylic group. The norfloxacin and their metal complexes have been biologically tested, which resulted in norfloxacin complexes showing moderate activity against the gram positive and gram negative bacteria as well as against fungi. (c) 2007 Elsevier B.V. All rights reserved.
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