Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 1, Pages 157-161Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0709036105
Keywords
-
Categories
Ask authors/readers for more resources
The V2 protein of tomato yellow leaf curl geminivirus (TYLCV) functions as an RNA-silencing suppressor that counteracts the innate immune response of the host plant. The host-cell target of V2, however, remains unknown. Here we show that V2 interacts directly with SISGS3, the tomato homolog of the Arabidopsis SGS3 protein (AtSGS3), which is known to be involved in the RNA-silencing pathway. SISGS3 genetically complemented an AtSGS3 mutation and restored RNA silencing, indicating that SISGS3 is indeed a functional homolog of AtSGS3. A point mutant of V2 that is unable to bind SISGS3 also lost its ability to suppress RNA silencing, suggesting a correlation between the V2-SISGS3 interaction in planta and the suppressor activity of V2.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available