Journal
FEBS LETTERS
Volume 582, Issue 1, Pages 90-96Publisher
WILEY
DOI: 10.1016/j.febslet.2007.11.014
Keywords
adipose tissue; lipodystrophy; obesity; triaclyglycerol; phosphatidate phosphatase; transcriptional coactivator
Funding
- NHLBI NIH HHS [P01 HL028481-21A10003, P01 HL028481-220003, P01 HL028481-230003, P01 HL028481] Funding Source: Medline
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The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1 alpha and PPAR alpha. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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