Journal
FEBS LETTERS
Volume 582, Issue 1, Pages 142-151Publisher
WILEY
DOI: 10.1016/j.febslet.2007.06.079
Keywords
sleep; circadian rhythms; circadian clock genes; obesity; metabolic syndrome; sleep deprivation
Funding
- NIA NIH HHS [P01 AG11412] Funding Source: Medline
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In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesity and diabetes. The first part of this review will focus on studies that support the idea that sleep loss and obesity are interacting epidemics. The second part will discuss recent evidence that the circadian clock system plays a fundamental role in energy metabolism at both the behavioral and molecular levels. These lines of research must be seen as in their infancy, but nevertheless, have provided a conceptual and experimental framework that potentially has great importance for understanding metabolic health and disease. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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