被撤回的出版物: High-concentration supplemental perioperative oxygen and surgical site infection following elective colorectal surgery for rectal cancer: a prospective, randomized, double-blind, controlled, single-site trial (Retracted article. See vol. 215, pg. 534, 2018)

BACKGROUND: Perioperative supplemental oxygen has been proposed to decrease the incidence of surgical site infection (SSI) in colorectal surgery with controversial results. We have assessed the influence of hyperoxygenation on SSI by using the most homogeneous study population. METHODS: We studied, in a prospective randomized study, 81 patients, who underwent elective open infraperitoneal anastomosis for rectal cancer. Patients were assigned randomly to an oxygen/air mixture with a fraction of inspired oxygen (FiO(2)) of 30% (n = 41) or 80% (n = 40). Administration was commenced after induction of anesthesia and maintained for 6 hours after surgery. RESULTS: The overall wound infection rate was 21%: 11 patients (26.8%) had wound infections in the 30% FiO(2) group and 6 (15%) in the 80% FiO(2) group (P < .05). The risk of SSI was 41% lower in the 80% FiO(2) group. CONCLUSION: Supplemental 80% FiO(2) reduced postoperative SSI with few risks to the patient and little associated cost. (C) 2014 Elsevier Inc. All rights reserved.