Journal
BIOINFORMATICS
Volume 24, Issue 2, Pages 293-295Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btm571
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We present a software for combined synthesis, inference and simplification of signal transduction networks. The main idea of our method lies in representing observed indirect causal relationships as network paths and using techniques from combinatorial optimization to find the sparsest graph consistent with all experimental observations. We illustrate the biological usability of our software by applying it to a previously published signal transduction network and by using it to synthesize and simplify a novel network corresponding to activation-induced cell death in large granular lymphocyte leukemia.
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