Correlation of staging systems to survival in patients with resected hilar cholangiocarcinoma

BACKGROUND: We aimed to identify staging parameters associated with survival in patients with hilar cholangiocarcinoma. METHODS: Clinicopathologic characteristics were obtained retrospectively for all resected patients with Bismuth-Corlette III cholangiocarcinoma between 1993 and 2011. Patients were stratified by the American Joint Commission on Cancer (AJCC) (7th edition) and Memorial Sloan-Kettering Cancer Center (MSKCC) staging systems. Survival analyses tested the effects of clinicopathologic factors and staging covariates on recurrence-free and overall survival. RESULTS: Eighty patients (mean age 63 +/- 11 years, 63% male) underwent anatomic hepatectomy with bile duct resection/reconstruction for Bismuth-Corlette IIIa (53%) and IIIb (47%) cholangiocarcinoma. The median follow-up was 26 months (interquartile range = 12 to 50 months), and the median time to recurrence was 15 months (interquartile range - 6 to 38 months). Neither AJCC nor MSKCC staging systems were associated with recurrence-free survival (all P >= .059). MSKCC T-stage but not the AJCC staging system was associated with overall survival (P <= .026). CONCLUSIONS: MSKCC T-stage classification but not AJCC staging is independently associated with overall survival for patients after resection of hilar cholangiocarcinoma. (C) 2013 Elsevier Inc. All rights reserved.