4.6 Review

The emerging neuropathology of essential tremor

Journal

MOVEMENT DISORDERS
Volume 23, Issue 2, Pages 174-182

Publisher

WILEY
DOI: 10.1002/mds.21731

Keywords

essential tremor; pathology; cerebellum; Lewy body; neurodegeneration

Funding

  1. NIA NIH HHS [P01 AG007232-180010, P01 AG007232, P01 AG007232-160010, P01 AG007232-190010, P01 AG007232-200010, P01 AG007232-170010] Funding Source: Medline
  2. NINDS NIH HHS [R01 NS042859-03, R01 NS042859-01A2, R01 NS042859-02, R01 NS042859, R01 NS42859, R01 NS042859-05, R01 NS042859-04] Funding Source: Medline

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Essential tremor (ET) is one of the most prevalent neurological disorders. At the same time, it is among the most poorly-understood of these disorders. The underlying anatomical pathology of ET has been elusive until recently. Postmortem studies have begun to display some of the underlying brain changes in patients with this disease. These types of investigations are likely to lead the way to additional insights into the pathophysiology of ET and guide the development of therapies for this common movement disorder. (C) 2007 Movement Disorder Society.

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