Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 4, Pages 1466-1476Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja0775927
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Funding
- NCATS NIH HHS [TL1 TR000441] Funding Source: Medline
- NIBIB NIH HHS [EB-001466, R21 EB001466-02, R21 EB001466-01, R21 EB001466, R01 EB002067, EB-002067] Funding Source: Medline
- NIGMS NIH HHS [T32 GM07250, T32 GM007250] Funding Source: Medline
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Novel supramolecular coatings that make use of low-molecular weight ditopic monomers with guanine end groups are studied using fluid tapping AFM. These molecules assemble on highly oriented pyrolytic graphite (HOPG) from aqueous solutions to form nanosized banding structures whose sizes can be systematically tuned at the nanoscale by tailoring the molecular structure of the monomers. The nature of the self-assembly in these systems has been studied through a combination of the self-assembly of structural derivatives and molecular modeling. Furthermore, we introduce the concept of using these molecular assemblies as scaffolds to organize functional groups on the surface. As a first demonstration of this concept, scaffold monomers that contain a monomethyl triethyleneglycol branch were used to organize these functional units on a HOPG surface. These supramolecular grafted assemblies have been shown to be stable at biologically relevant temperatures and even have the ability to significantly reduce static platelet adhesion.
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