Journal
AMERICAN JOURNAL OF SURGERY
Volume 198, Issue 1, Pages 1-5Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2008.07.021
Keywords
Collagen; Inguinal hernia; Case-control study
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BACKGROUND: The aim of this study was to analyze the constituents of total and types I and III collagen fibers in the transversalis fascias of patients with indirect inguinal hernias, compared with samples removed from nonherniated cadavers. METHODS: Biopsy samples from 26 patients and 26 cadavers were analyzed. Hematoxylin-eosin and picrosirius staining techniques were used. The images obtained were analyzed using a video morphometric technique to determine the constituents of total collagen and-types I and III collagen in the transversalis fascia. The picrosirius-stained tissues were submitted to observation under polarized-light microscopy. RESULTS: The results showed 17.3% less total collagen in patients with hernias compared with the control group (P <.01). Type I collagen in patients with indirect inguinal hernias was 23.7% less than the control group (P <.01), type III collagen was 6.4% less in the controls (P <.01). CONCLUSION: The lower percentages of total collagen and type I collagen in the transversalis fascias of patients with indirect inguinal hernias could be a factor in hernia formation. (C) 2009 Published by Elsevier Inc.
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