Journal
JOURNAL OF HUMAN HYPERTENSION
Volume 22, Issue 2, Pages 122-125Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.jhh.1002286
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Funding
- NHLBI NIH HHS [HL068041, HL079929-01A2] Funding Source: Medline
- NIDDK NIH HHS [K08 DK073381] Funding Source: Medline
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Animal and human data suggest a link between endogenous acid production with elevations in blood pressure and the development of hypertension; increases in endogenous organic acid production can lead to a higher anion gap. We studied the cross-sectional association between the serum anion gap and blood pressure among 1057 nondiabetic patients who were not taking antihypertensive drugs, and who received their care at a multisite, multispecialty group practice in eastern Massachusetts. Using linear regression controlling for age, sex, race, BMI, estimated GFR and presence of impaired fasting glucose, every 1mEq l(-1) higher serum anion gap was associated with a 0.27mm Hg (P = 0.08) higher systolic, 0.20mm Hg (P = 0.05) higher diastolic and 0.22mm Hg (P = 0.04) higher mean arterial pressure; these results suggest that endogenous acid production may raise the risk of hypertension.
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