Journal
POLYMER INTERNATIONAL
Volume 57, Issue 2, Pages 268-274Publisher
WILEY
DOI: 10.1002/pi.2339
Keywords
methoxy poly(ethylene glycol)-block-poly(D,L-lactic acid); diblock copolymer; nanoparticles transdermal drug delivery systems; paclitaxel
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This work evaluates the transdermal drug delivery properties of amphiphilic copolymer self-assembled nanoparticles by skin penetration experiments in vitro. Paclitaxel-loaded methoxy poly(ethylene glycol)-block-poly(D,L-lactic acid) diblock copolymer nanoparticles (PNPs) were prepared by a solid dispersion technique and were applied to the surface of excised full-thickness rat skin in Franz diffusion cells. HPLC, transmission electron microscopy, Fourier transform infrared spectroscopy and H-1 NMR were used to assay the receptor fluid. The results show that the amphiphilic copolymer nanoparticles with the entrapped paclitaxel are able to penetrate rat skin. Ethanol can improve the delivery of PNPs and increase the cumulative amount of paclitaxel in the receptor fluid by 3 times. Fluorescence microscopy measurements indicate that the PNPs can penetrate the skin not only via appendage routes including sweat ducts and hair follicles but also via epidermal routes. (C) 2007 Society of Chemical Industry.
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