Journal
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
Volume 34, Issue 1, Pages 85-102Publisher
HUMANA PRESS INC
DOI: 10.1007/s12016-007-8013-6
Keywords
hepatitis B virus; autoimmune disease; autoimmune hepatitis; systemic lupus erythomatosus; antiphospholipid syndrome; polyarteritis nodosa; rheumatoid arthritis; type I diabetes; multiple sclerosis; thyroid disease and uveitis
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The etiology and pathogenesis of autoimmune diseases have long been an enigmatic subject that have involved genetic and environmental factors. Recent intriguing data has contributed to the mechanisms involved, including the relationship of infectious agents and loss of tolerance. This loss of tolerance is illustrated by the data on the immune response to Hepatitis B virus such as the molecular mimicry between HBV antigens and self proteins, the generation of immune complexes between HBV antigens and antibodies, and apoptosis/tissue damage resulting in the exposure of intracellular antigens to the immune system. In this paper, we review the current database related to HBV infection and a variety of autoirnmune conditions, including autoirnmune hepatitis, systemic lupus erythematosus, aplastic anemia, antiphospholipid syndrome, polyarteritis nodosa, rheumatoid arthritis, type 1 diabetes, multiple sclerosis, thyroid disease and uveitis.
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