Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 83, Issue 2, Pages 365-367Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.clpt.6100460
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When I was invited to author an ethics policy piece on the approach to high-risk molecules as a contribution to the theme of Innovation in Drug Development of this Clinical Pharmacology & Therapeutics issue, I thought there was a need to evaluate whether questioning the transition from preclinical to clinical development after the TGN 1412 serious adverse event may freeze the development of innovating tools in drug development.
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