4.2 Article

First total synthesis of a pentasaccharide repeating unit of the O-antigen of Hafnia alvei PCM 1529

Journal

GLYCOCONJUGATE JOURNAL
Volume 25, Issue 2, Pages 111-119

Publisher

SPRINGER
DOI: 10.1007/s10719-007-9061-0

Keywords

carbohydrates; oligosaccharides; total synthesis; vaccines; Hafnia alvei

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A pentasaccharide repeating unit of the O-antigen of Hafnia alvei has been synthesized in a concise manner. High yielding glycosylation steps and minimum number of protecting group manipulation steps are the key features of this synthesis. A two-step, one-pot phase transfer oxidation protocol has been applied for the preparation of D-galacturonic acid.

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