Journal
RNA
Volume 14, Issue 2, Pages 197-203Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.868008
Keywords
mRNA splicing; systems biology; genome-wide; alternative splicing regulation; microarrays; RNA network
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Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with broad roles in development and disease. Systems-wide experimental methods have started to define how global splicing regulation shapes complex biological properties and pathways. Here, we review these approaches, describe recent insights they have yielded, and discuss avenues of future investigation.
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