Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 3, Pages 1605-1609Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01876-07
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In the event of a new influenza pandemic, vaccines whose antigenicities match those of circulating strains must be rapidly produced. Here, we established an alternative reverse genetics system for influenza virus using the canine polyrnerase I (Poll) promoter sequence that works efficiently in the Madin-Darby canine kidney cell line, a cell line approved for human vaccine production. Using this system, we were able to generate H5N1 vaccine seed viruses more efficiently than can be achieved with the current system that uses the human PolI promoter in African green monkey Vero cells, thus improving pandemic vaccine production.
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