Journal
NEUROSCIENTIST
Volume 14, Issue 1, Pages 12-18Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858407307354
Keywords
mitochondria; axon; peripheral neuropathy; neurodegeneration
Categories
Funding
- NINDS NIH HHS [K08NS055980] Funding Source: Medline
Ask authors/readers for more resources
Peripheral neuropathy is perhaps the archetypal disease of axonal degeneration, characteristically involving degeneration of the longest axons in the body. Evidence from both inherited and acquired forms of peripheral neuropathy strongly supports that the primary pathology is in the axons themselves and points to disruption of axonal transport as an important disease mechanism. Recent studies in human genetics have further identified abnormalities in mitochondrial dynamics-the fusion, fission, and movement of mitochondria - as a player in the pathogenesis of inherited peripheral neuropathy. This review provides an update on the mechanisms of mitochondrial trafficking in axons and the emerging relationship between the disruption of mitochondrial dynamics and axonal degeneration. Evidence suggests mitochondria are a critical cargo whose transport is necessary for proper axonal and synaptic function. Importantly, understanding the regulation of mitochondrial movement and the consequences of decreased axonal mitochondrial function may define new paths for therapeutic agents in peripheral neuropathy and other neurodegenerative diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available