Journal
GLYCOCONJUGATE JOURNAL
Volume 25, Issue 2, Pages 157-166Publisher
SPRINGER
DOI: 10.1007/s10719-007-9068-6
Keywords
saponin; synthesis; H2SO4-silica; growth-inhibitory
Categories
Ask authors/readers for more resources
Simple and convergent synthesis of a tetra- and a trisaccharide portions of an antitumor compound Julibroside J(28), isolated from Albizia julibrissin, that showed significant in vitro antitumor activity against HeLa, Bel-7402 and PC-3M-1E8 cancer cell lines is reported. The tetrasaccharide has been synthesized as its p-methoxyphenyl glycoside starting from commercially available D-glucose, L-rhamnose and L-arabinose. The trisaccharide part has been synthesized from commercially available N-acetyl D-glucosamine, D-fucose and D-xylose using simple protecting group manipulations. Sulfuric acid immobilized on silica has been used successfully as a Bronsted acid catalyst for the crucial glycosylation steps.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available