Journal
BIOTECHNOLOGY LETTERS
Volume 30, Issue 2, Pages 187-196Publisher
SPRINGER
DOI: 10.1007/s10529-007-9524-1
Keywords
endoplasmic reticulum associated protein degradation; heterologous protein production; molecular chaperone; protein folding; unfolded protein response
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Funding
- Biotechnology and Biological Sciences Research Council [BB/D01588X/1, BB/E006035/1, BB/C513418/1] Funding Source: researchfish
- BBSRC [BB/E006035/1, BB/D01588X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C513418/1, BB/D01588X/1] Funding Source: Medline
- Wellcome Trust [079821] Funding Source: Medline
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The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.
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