Journal
BRITISH JOURNAL OF SURGERY
Volume 95, Issue 2, Pages 229-236Publisher
WILEY
DOI: 10.1002/bjs.5917
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- National Institute for Health Research [NF-SI-0507-10161] Funding Source: researchfish
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Background: Extramural vascular invasion (EMVI) is a poor prognostic feature in colorectal cancer. The accuracy of magnetic resonance imaging (MRI) in detecting EMVI and predicting relapse-free survival (RFS) was compared retrospectively with the histological reference standard. Methods: Preoperative magnetic resonance images from patients diagnosed with rectal and sigmoid cancer were reviewed and an MRI-EMVI score (range 0 to 4) was assigned. Comparison was made with histology and clinical outcome. Results: Some 142 patients with a median follow-up of 3.3 (range 0.9-5.7) years were reviewed. Histological. EMVI was reported in a quarter of patients. The sensitivity and specificity of MRI detection of EMVI in 94 patients undergoing primary surgery were 62 and 88 per cent respectively. On univariable analysis, RFS at 3 years was 35 per cent for patients with an MRI-EMVI score of 3-4, compared with 74 per cent for those with a score of 0-2 (P < 0.001), similar to values in patients with positive and negative histological EMVI status respectively (34 versus 73.7 per cent; P < 0.001). Conclusion: High MRI-EMVI scores may help in predicting disease relapse.
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