Implementing representations of space in economic geography

Since spatial issues have become more important in economic theory, it is of interest to examine how space is represented. In empirical terms, this concerns at least the representation of distance and proximity. Both of these may be represented and operationalized in a number of ways, with possible consequences for inferences when modeling. This question is related to the representation of spatial entities, and itself plays into the treatment of spatial dependence as substantive and/or just a nuisance. Because other disciplines face similar questions-for example ecology or epidemiology, their conceptualizations and operationalizations of space will also be used for comparative purposes.