Journal
NUCLEIC ACIDS RESEARCH
Volume 36, Issue 3, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkm1063
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Funding
- NIA NIH HHS [AG01228, R01 AG001228] Funding Source: Medline
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Telomeres terminate in 3 overhangs that function in end protection and the formation of t-loops. Determining the steps and factors involved in overhang processing is compromised by the inability to easily and accurately determine overhang size in the presence of many kilobases of double-stranded telomeric DNA. We here describe the use of a double-strand specific nuclease (DSN) that entirely digests double-stranded DNA including telomeres, leaving the overhangs intact so that they can be measured.
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