Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 28, Issue 2, Pages 280-290Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/sj.jcbfm.9600531
Keywords
fMRI; human brain; neuronal suppression; neurovascular coupling; paired-stimulus paradigm; visual cortex
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Funding
- NCRR NIH HHS [R01 P41 RR08079] Funding Source: Medline
- NIBIB NIH HHS [R01 EB00329, R01 EB00513, R01 EB00178] Funding Source: Medline
- NINDS NIH HHS [R01 P30NS057091, R01 NS41262, R01 NS39043] Funding Source: Medline
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In this study, the neurovascular coupling relationship was noninvasively studied in the human visual cortex. Graded neuronal/hemodynamic suppression conditions were generated using a paired-stimulus paradigm. Visual evoked potential was measured to quantify neuronal activity. Hemodynamic activities were measured and quantified by perfusion and blood oxygenation level-dependent changes. All quantification was normalized to the same activation condition induced by a single stimulus paradigm within each experimental session. This experiment design eliminated the confounding factors such as anesthesia and inconsistent neurovascular coupling patterns within and/or among tasks. The results reveal that (i) there is a tight neurovascular coupling at graded neuronal suppression conditions; (ii) the neurovascular coupling relationship contains a subtle, but significant, nonlinear component; and (iii) the linear model, nevertheless, is still a good approximation reflecting the neurovascular coupling relationship. This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions.
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