Journal
VASCULAR HEALTH AND RISK MANAGEMENT
Volume 4, Issue 1, Pages 39-57Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/vhrm.2008.04.01.39
Keywords
high density lipoprotein cholesterol (HDL-C); coronary; atherosclerosis; reverse cholesterol transport
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Since the pioneering work of John Gofman in the 1950s, our understanding of high density lipoprotein cholesterol (HDL-C) and its relationship to coronary heart disease (CHD) has grown substantially. Numerous clinical trials since the Framingham Study in 1977 have demonstrated an inverse relationship between HDL-C and one's risk of developing CHD. Over the past two decades, preclinical research has gained further insight into the nature of HDL-C metabolism, specifically regarding the ability of HDL-C to promote reverse cholesterol transport (RCT). Recent attempts to harness HDL's ability to enhance RCT have revealed the complexity of HDL-C metabolism. This review provides a detailed update on HDL-C as an evolving therapeutic target in the management of cardiovascular disease.
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