Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 28, Issue 5, Pages 1565-1572Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.01038-07
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Funding
- NICHD NIH HHS [P30 HD026979, HD26979] Funding Source: Medline
- NINDS NIH HHS [R01 NS046616] Funding Source: Medline
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Bone morphogenic proteins (BMPs) play pleotrophic roles in nervous system development, and their signaling is highly regulated at virtually every step in the pathway. We have cloned a novel gene, Sizn1 (Smad-interacting zinc finger protein), which functions as a transcriptional coactivator of BMP signaling. It positively modulates BNIP signaling by interacting with Small family members and associating with CBP in the transcription complex. Sizn1 is expressed in the ventral embryonic forebrain, where, as we will show, it contributes to BMP-dependent, cholinergic-neuron-specific gene expression. These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development.
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