Journal
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Volume 50, Issue 3, Pages 471-482Publisher
AMER THORACIC SOC
DOI: 10.1165/rcmb.2013-0348TR
Keywords
cigarette smoke; inflammation; autophagy; DNA damage; cellular senescence
Funding
- American Lung Association biomedical research grant [RG-231988-N, AG037768, HL068111, ES015482]
- Tobacco Master Settlement
- University of New Mexico
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Cigarette smoke contains numerous chemical compounds, including abundant reactive oxygen/nitrogen species and aldehydes, and many other carcinogens. Long-term cigarette smoking significantly increases the risk of various lung diseases, including chronic obstructive pulmonary disease and lung cancer, and contributes to premature death. Many in vitro and in vivo studies have elucidated mechanisms involved in cigarette smoke-induced inflammation, DNA damage, and autophagy, and the subsequent cell fates, including cell death, cellular senescence, and transformation. In this Translational Review, we summarize the known pathways underlying these processes in airway epithelial cells to help reveal future challenges and describe possible directions of research that could lead to better management and treatment of these diseases.
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