Journal
INTENSIVE CARE MEDICINE
Volume 34, Issue 3, Pages 468-475Publisher
SPRINGER
DOI: 10.1007/s00134-007-0902-x
Keywords
traumatic brain injury; hypopituitarism; magnetic resonance imaging
Categories
Funding
- Medical Research Council [G9439390, G0001237, G0601025, G0600986] Funding Source: Medline
- MRC [G0601025, G0600986, G0001237, G9439390] Funding Source: UKRI
- Medical Research Council [G0601025, G0001237, G9439390, G0600986] Funding Source: researchfish
Ask authors/readers for more resources
Objective: The objective was to study the anatomical changes in the pituitary gland following acute moderate or severe traumatic brain injury (TBI). Design: Retrospective, observational, case-control study. Setting: Neurosciences Critical Care Unit of a university hospital. Patients: Forty-one patients with moderate or severe TBI who underwent magnetic resonance imaging (MRI) during the acute phase (less than seven days) of TBI. MRI scans of 43 normal healthy volunteers were used as controls. Interventions: None. Measurements and main results: Patient demographics, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Injury Severity Score (ISS), post-resuscitation Glasgow Coma Score (GCS), Glasgow Outcome Score (GOS), mean intracranial pressure (ICP), mean cerebral perfusion pressure (CPP), computed tomography (CT) data, pituitary gland volumes and structural lesions in the pituitary on MRI scans. The pituitary glands were significantly enlarged in the TBI group (the median and interquartile range were as follows: cases 672mm(3) (range 601-783mm3) and controls 552mm(3) (range 445-620mm(3)); p value<0.0001). APACHE II, GCS, GOS and ICP were not significantly correlated with the pituitary volume. Twelve of the 41 cases (30%) demonstrated focal changes in the pituitary gland (haemorrhage/haemorrhagic infarction (n=5), swollen gland with bulging superior margin (n=5), heterogeneous signal intensities in the anterior lobe (n=2) and partial transection of the infundibular stalk (n=1). Conclusions: Acute TBI is associated with pituitary gland enlargement with specific lesions, which are seen in approximately 30% of patients. MRI of the pituitary may provide useful information about the mechanisms involved in post-traumatic hypopituitarism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available