Independent prognostic value of the ambulatory arterial stiffness index and aortic pulse wave velocity in a general population

Aortic pulse wave velocity (aPWV) and the Ambulatory Arterial Stiffness Index (AASI) both reflect arterial stiffness and predict cardiovascular outcome. To elucidate the independent contributions of both indexes to risk stratification, we studied a random population sample of 1678 Danes. In multivariate-adjusted Cox regression models including both indexes, AASI (standardized hazard ratio, 1.68; P = 0.01) but not aPWV (0.91; P = 0.62) predicted stroke, whereas the opposite was true for the composite of all cardiovascular events (aPWV, 1.15; P = 0.03 and AASI, 1.04; P = 0.68).