Journal
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Volume 39, Issue 6, Pages 644-647Publisher
AMER THORACIC SOC
DOI: 10.1165/rcmb.2008-0169TR
Keywords
MUC1 mucin; antiinflammatory; airway infection
Funding
- U.S. Public Health Service [HL-47125, HL-81825]
- Cystic Fibrosis Foundation
- [Al-72291]
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MUC1 is a membrane-tethered mucin expressed on the surface of epithelial cells lining mucosal surfaces. Recent studies have begun to elucidate the physiologic function of MUC1 in the airways, pointing to an antiinflammatory role that is initiated late in the course of bacterial infection and is mediated through inhibition of TLR signaling. These new findings have great potential for clinical applications in controlling excessive and prolonged lung inflammation. This review briefly summarizes the protein structural features of MUC1 relevant to its function, the discovery of its antiinflammatory properties, and potential directions for future avenues of study.
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