Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 5, Pages 2560-2564Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02123-07
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Funding
- NCI NIH HHS [R01 CA071878, R01CA71878] Funding Source: Medline
- NINDS NIH HHS [R01 NS043097, R01NS43097, F31 NS053340] Funding Source: Medline
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For the human polyomaviruses JC virus (JCV) and BK virus (BKV), the first step to a successful infection involves binding to sialic acid moieties located on the surfaces of host cells. By stripping and then reconstituting specific sialic acid linkages on host cells, we show that JCV uses both alpha(2,3)-linked and alpha(2,6)-linked sialic acids on N-linked glycoproteins to infect cells. For both JCV and BKV, the sialic acid linkages required for cell surface binding directly correlate with the linkages required for infection. In addition to sialic acid linkage data, these data suggest that the third sugar from the carbohydrate chain terminus is important for virus binding and infection.
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