Journal
PITUITARY
Volume 11, Issue 1, Pages 85-87Publisher
SPRINGER
DOI: 10.1007/s11102-007-0022-1
Keywords
prolactinoma; gangliocytoma; pituitary
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The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of the gangliocytoma demonstrated expression of enkephalin, a product of proopiomelanocortin known to be a prolactin secretagogue. We postulate that in this patient there may be a link between gangliocytoma enkephalin and prolactin hypersecretion.
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