Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 186, Issue 1, Pages 11-16Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.201203-0455PP
Keywords
lung inflammation; cardiovascular disease; atherosclerosis; COPD
Categories
Funding
- Canada Research Chair in COPD
- Canadian Institutes of Health Research/GSK Professorship in COPD
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Acute and chronic lung inflammation is an underrecognized risk factor for cardiovascular disease. Yet, there are compelling epidemiological data to indicate that airway exposures to cigarette smoke, air pollution particles, and viral and bacterial pathogens are strongly related to acute ischemic events. Over the past 10 years, there have been important human and animal studies that have provided experimental evidence to support a causal link. In this article, we review the epidemiological data for the relationship between lung inflammation and cardiovascular disease and provide plausible mechanistic pathways by which acute and chronic inflammation contributes to the development of acute cardiovascular syndromes.
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