Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 183, Issue 2, Pages 171-178Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.201005-0757OC
Keywords
acetaminophen; ISAAC; asthma; rhinoconjunctivitis; eczema
Categories
Funding
- ISAAC Phase Three
- ISAAC International Data Centre (IIDC) is The BUPA Foundation
- Health Research Council of New Zealand
- Asthma and Respiratory Foundation of New Zealand
- Child Health Research Foundation
- Hawke's Bay Medical Research Foundation
- Waikato Medical Research Foundation
- Glaxo Wellcome New Zealand
- NZ Lottery Board
- Astra Zeneca New Zealand
- Glaxo Wellcome International Medical Affairs
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Rationale There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma. Objectives: To investigate the risk of asthma and other allergic disorders associated with the current use of acetaminophen in 13- to 14-year-old children in different populations worldwide. Methods: As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three, 13- to 14-year-old children completed written and video questionnaires obtaining data on current symptoms of asthma, rhinoconjunctivitis, and eczema, and a written environmental questionnaire obtaining data on putative risk factors, including acetaminophen use in the past 12 months. Measurements and Main Results: The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression. A total of 322,959 adolescent children from 113 centers in 50 countries participated. In the multivariate analyses the recent use of acetaminophen was associated with an exposure-dependent increased risk of current asthma symptoms (OR, 1.43 [95% confidence interval, 1.33-1.531 and 2.51 [95% confidence interval, 2.33-2.70] for medium and high versus no use, respectively). Acetaminophen use was also associated with an exposure-dependent increased risk of current symptoms of rhinoconjunctivitis and eczema. Conclusions: Acetaminophen use may represent an important risk factor for the development and/or maintenance of asthma, rhinoconjunctivitis, and eczema in adolescent children.
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