Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 184, Issue 10, Pages 1107-1113Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.201106-0995PP
Keywords
tuberculosis; HIV/AIDS; drug development
Categories
Funding
- National Institutes of Health AIDS Clinical Trials group [U01 AI69502]
- National Institutes of Health [K24 AI51982]
- Pfizer
- Merck
- Gliead
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Anunprecedented number of new tuberculosis (TB) medications are currently in development, and there will be great pressure to deploy these new drugs among all populations after their efficacy is demonstrated. People living with HIV experience a large burden of TB and have a particularly pressing need for TB treatments that are shorter and less toxic. In addition, all people living with HIV now require antiretroviral therapy during TB treatment. A roadmap of the research, programmatic, and regulatory considerations includes the following: (1) inclusion of people living with HIV early in clinical trials for treatment and prevention using new TB medications, (2) prioritization of key studies of HIV-TB drug interactions and interactions between new TB agents, and (3) optimization of clinical trial infrastructure, laboratory capacity, and drug susceptibility testing.
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