Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 184, Issue 6, Pages 656-661Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.201101-0111OC
Keywords
atopy; blood eosinophils; eczema; neonates; urinary eosinophil protein X
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Funding
- Lundbeck Foundation
- Pharmacy Foundation
- Danish Medical Research Council
- Danish Pediatric Asthma Center
- Danish Lung Association
- Hans Skoubys og hustru Emma Skoubys Fond
- Oda Pedersens Legat
- Lundbeck Foundation [R16-2007-1694] Funding Source: researchfish
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Rationale: Biomarkers predicting development of atopic disease are needed for targeted preventive measures and to study if disease pathology may be active before onset of symptoms. Objectives: To investigate whether eosinophil protein X, leukotriene-C4/D4/E4, and 11 beta-prostaglandin (PG) F(2 alpha) (PGD(2) metabolite) assessed in urine from healthy at-risk neonates precede development of atopic disease during the first 6 years of life. Methods: We measured eosinophil protein X (n = 369), leukotriene-C4/D4/E4 (n = 367), and 11b-PGF(2 alpha) (n = 366) in urine from 1-monthold children participating in the Copenhagen Prospective Studies on Asthma in Childhood birth cohort. Clinical data on development of allergic sensitization, allergic rhinitis, nasal eosinophilia, blood eosinophilia, eczema, troublesome lung symptoms (significant cough or wheeze or dyspnea), and asthma were collected prospectively until age 6 years. Associations between urinary biomarkers and development of atopic traits were investigated using general estimating equations, logistic regression, and Cox regression. Measurements and Main Results: Eosinophil protein X in the urine of the asymptomatic 1-month-old neonates was significantly associated with development of allergic sensitization (odds ratio, 1.49; 95% confidence interval [CI], 1.08-1.89), nasal eosinophilia (odds ratio, 3.2; 95% CI, 1.2-8.8), and eczema (hazard ratio, 1.4; 95% CI, 1.0-2.0), but not with allergic rhinitis, asthma, or blood eosinophilia. Neither leukotriene-C4/D4/E4 nor 11b-PGF2 alpha was associated with any of the atopic phenotypes. Conclusions: Eosinophil protein X in urine from asymptomatic neonates is a biomarker significantly associated with later development of allergic sensitization, nasal eosinophilia, and eczema during the first 6 years of life. These findings suggest activation of eosinophil granulocytes early in life before development of atopy-related symptoms.
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