Journal
JOURNAL OF VIROLOGY
Volume 82, Issue 5, Pages 2208-2217Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01718-07
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Funding
- NCI NIH HHS [5 T32 CA009056-29, T32 CA009056] Funding Source: Medline
- NIAID NIH HHS [T32 AI007126, R0I-AI069120, R01 AI069120, 5T32AI007126-30] Funding Source: Medline
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Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.
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