Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 71, Issue 6, Pages 495-504Publisher
WILEY-BLACKWELL
DOI: 10.1111/aji.12247
Keywords
Anatomy; female genital tract; HIV; hormones; STI; women
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The female genital tract undergoes anatomic changes from birth through menopause. Concurrently, the relative levels and roles of estradiol and progesterone dramatically change during the female life cycle. This review provides a conceptual overview of clinically relevant anatomic and hormonal changes in the female genital tract, and how these changes may affect HIV-1 pathogenesis, transmission, and mucosal immunology and protection against HIV and STIs across the female life cycle.
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