Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 72, Issue 4, Pages 359-375Publisher
WILEY
DOI: 10.1111/aji.12275
Keywords
Embryonic development; first trimester; long non-coding RNA (lncRNA); pathogenesis; pathways; spontaneous abortion
Categories
Funding
- Shijiazhuang Maternal and Obstetric Hospital
- March of Dimes Global Network for Maternal and Infant Health (MOD-GNMIH), Peking University Center of Medical Genetics (PUCMG)
- New York State Office for People with Developmental Disabilities (NYS OPWDD)
Ask authors/readers for more resources
Problem Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been investigated the possible involvement of lncRNA in pregnancy loss. Method of StudySixteen pairs of pregnancies with spontaneous abortions (SA) and induced abortions (IA) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human LncRNA Array was employed to profile genomewide lncRNAs, which were then validated by RT-PCR. ResultsDifferentially expressed lncRNAs were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation. ConclusionsInfection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available