Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 73, Issue 6, Pages 577-581Publisher
WILEY
DOI: 10.1111/aji.12353
Keywords
IL-1 ss; inflammasome; NLRP1; preeclampsia
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ProblemAugmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome' genes and preeclampsia. Method of studySelected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and ConlclusionsThe NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR=1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.
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