Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 71, Issue 6, Pages 575-588Publisher
WILEY
DOI: 10.1111/aji.12250
Keywords
Antimicrobials; cervical-vaginal lavage; female reproductive tract; HIV; hormones; sexually transmitted infections
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The mucosal microenvironment of the female reproductive tract (FRT) is rich in secreted endogenous antimicrobials that provide the first line of defense against pathogens. This review focuses on the spectrum of secreted antimicrobials found in the FRT that have anti-HIV functions and are regulated by the natural hormonal changes in women's life cycle. Understanding the complex nature of FRT, mucosal microenvironment will enable us to better design therapeutic interventions for women against sexually transmitted pathogens.
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