Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 73, Issue 5, Pages 445-459Publisher
WILEY
DOI: 10.1111/aji.12350
Keywords
Allergy; fetal programming of diseases; gene expression; placenta; Th2
Categories
Funding
- Swedish Research Council [73X-15335-01A, 74X-20146-01-2]
- National Swedish Association against Allergic Diseases
- National Heart and Lung Association
- Vardal Foundation - for Health Care Sciences and Allergy Research
- Olle Engkvist Foundation
- Cancer and Allergy Association
- Samariten Foundation
- Queen Silvia Research Foundation
- Ellen, Walter and Lennart Hesselmans foundation
- County Council of Ostergotland
- Boehringer Ingelheim Fonds
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ProblemHow maternal allergy affects the systemic and local immunological environment during pregnancy and the immune development of the offspring is unclear. Method of studyExpression of 40 genes was quantified by PCR arrays in placenta, peripheral blood mononuclear cells (PBMC), and cord blood mononuclear cells (CBMC) from 7 allergic and 12 non-allergic women and their offspring. ResultsPlacental gene expression was dominated by a Th2-/anti-inflammatory profile, irrespectively of maternal allergy, as compared to gene expression in PBMC. p35 expression in placenta correlated with fetal Tbx21 (=-0.88, P<0.001) and IL-5 expression in PBMC with fetal galectin1 (=0.91, P<0.001). Increased expression of Th2-associated CCL22 in CBMC preceded allergy development. ConclusionsGene expression locally and systemically during pregnancy was partly associated with the offspring's gene expression, possibly indicating that the immunological milieu is important for fetal immune development. Maternal allergy was not associated with an enhanced Th2 immunity in placenta or PBMC, while a marked prenatal Th2 skewing, shown as increased CCL22 mRNA expression, might contribute to postnatal allergy development.
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