Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 69, Issue 3, Pages 264-271Publisher
WILEY-BLACKWELL
DOI: 10.1111/aji.12069
Keywords
B7; CD28; indoleamine-2; 3-dioxygenase; monocyte; pre-eclampsia; T cell
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Funding
- OTKA [101661]
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
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Problem We determined the frequency of activated (CD11b+) monocytes expressing B7-1, B7-2, B7-H1, and B-7H2, and that of T cells and T helper cells expressing CD28, CTLA-4, PD-1, and ICOS in peripheral blood samples from normal pregnant (NP) and pre-eclamptic (PE) women. We also examined the intracellular expression of indoleamine-2,3-dioxygenase (IDO). Method of study We measured the expression of the above markers using flow-cytometry in peripheral blood samples from 20 NP and 20 PE women in the third trimester. Results The frequency of B7-1 and B7-2 expressing activated monocytes and that of IDO expressing T-lymphocytes was lower in PE than in NP. Conclusion Lower expression of B7-1 and B7-2 proteins on peripheral monocytes in PE might indicate a secondary regulatory mechanism in response to the ongoing systemic maternal inflammation. IDO plays an important role in the pregnancy-specific immune tolerance, and might be a contributing factor in the pathogenesis of PE.
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