Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 66, Issue 5, Pages 349-362Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0897.2011.01010.x
Keywords
Animal model; immune modulation; immunodeficiency; pregnancy
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Funding
- National Natural Science Foundation of China [30730087, 30872761]
- New Cutting-Edge Technology Project [SHDC12010122]
- Natural Science Foundation of Shanghai Science and Technology Department [08zrl1413400]
- Focus Construction Subject of Shanghai Education Department
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Problem FTY720 is known as an agonist of sphingosine-1-phosphate (S1P) receptor, but little is known about the possibility that FTY720 induces the conversion of conventional Foxp3) CD4(+) T cells to Foxp3(+) regulatory T cells in non-obese diabetic (NOD) mice. Method of study FTY720 treatment was performed using Foxp3(-)CD4(+) T cells purified from NOD mice. Results FTY720 caused an increase in Foxp3(+) Treg cells in lymphoid organs in NOD mice. FTY720 effectively induced Foxp3 expression in Foxp3(-)CD4(+) T cells both in vitro and in vivo, an effect that was inhibited by a TGF-beta-neutralizing antibody or the proinflammatory cytokine IL-6. T-cell-mediated embryo rejection in NOD mice was prevented upon FTY720 treatment. Conclusions The use of FTY720 along with Ag administration may represent a useful therapeutic strategy to selectively expand Ag-specific Foxp3(+) Tregs to intervene autoimmune and infectious diseases.
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