Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 63, Issue 6, Pages 425-433Publisher
WILEY
DOI: 10.1111/j.1600-0897.2010.00836.x
Keywords
Cytokines; inflammation; macrophages; placenta; pregnancy; TLR
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Funding
- National Institute of Health, NICDH [P01HD054713, 3N01 HD23342]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services
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P>Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman's susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the 'classical concepts' to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios.
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