Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 62, Issue 3, Pages 139-146Publisher
WILEY
DOI: 10.1111/j.1600-0897.2009.00723.x
Keywords
Apoptosis; first trimester trophoblast; influenza A virus
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Funding
- Ministry of Heath, Labor and Welfare
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Honjo International Scholarship Foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD054713] Funding Source: NIH RePORTER
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Problem Epidemiological data Suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown. Method of study The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)-G were also examined. Results Intracellular localization of viral proteins was observed. Twenty-four hours virus was detected in Culture media while most cells fell after inoculation, into apoptosis. During apoptosis, expression of HLA-G was unchanged. Conclusion We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA-G expression and subsequent rejection by maternal immune system.
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