Journal
AMERICAN JOURNAL OF PUBLIC HEALTH
Volume 104, Issue 8, Pages E43-E50Publisher
AMER PUBLIC HEALTH ASSOC INC
DOI: 10.2105/AJPH.2014.302034
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Funding
- Vitamin D Council (San Luis Obispo, CA)
- UV Foundation (McLean, VA)
- Bio-Tech Pharmacal (Fayetteville, AR)
- Vitamin D Society (Canada)
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We examined the relationship between serum 25-hydroxyvitamin D (25[OH] D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 or more categories of 25(OH) D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for all-cause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH) D was 1.9 (95% confidence interval = 1.6, 2.2; P < .001). Serum 25 (OH) D concentrations less than or equal to 30 ng/mL were associated with higher all-cause mortality than concentrations greater than 30 ng/mL (P < .01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
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